Why America’s Health Crisis Is an Incentive Problem
a16z PodcastFull Title
Why America’s Health Crisis Is an Incentive Problem
Summary
The episode argues that America's health crisis, particularly chronic diseases, is primarily an environmental and incentive problem, not just a healthcare issue.
The discussion explores how the food system, lack of preventative care incentives, and environmental toxins contribute to poor health, and introduces TruMed as a company aiming to shift incentives towards lifestyle interventions.
Key Points
- The modern U.S. environment is structurally designed to make people unhealthy, leading to high rates of chronic disease, obesity, and poor health outcomes compared to previous generations.
- The 1970s marked a turning point for American health, with major food companies prioritizing profit by replacing real ingredients with cheaper, processed alternatives like high-fructose corn syrup and soybean oil due to shareholder pressure and optimized earnings per share.
- US crop subsidies for corn, soy, and wheat artificially lower their cost, encouraging their widespread use in processed foods and contributing to the prevalence of unhealthy ingredients in the food system.
- The current healthcare system incentivizes treating chronic diseases after they manifest rather than preventing them, as managing conditions like heart attacks is far more profitable than investing in preventative measures like exercise or healthy eating.
- TruMed aims to solve this by enabling individuals to use tax-advantaged FSA/HSA dollars for lifestyle interventions like gym memberships and healthier food, treating prevention as a viable healthcare intervention.
- The mismatch between human genes and the modern, toxic environment is a root cause of chronic disease, similar to how zoo animals exhibit health problems absent in their wild counterparts.
- Addressing the health crisis requires systemic changes, including fixing crop subsidies, increasing investment in preventative care, and enacting stricter regulations on environmental toxins, mirroring the EU's approach to chemical safety.
- GLP-1 medications like Ozempic can be a useful tool for initiating weight loss but are not a holistic solution, as they don't address the underlying issues of poor diet and environmental factors.
- Psychedelics show promise as a powerful mental health intervention, especially for conditions like PTSD and depression, and should be further researched and integrated into treatment options.
- Metabolic psychiatry highlights the significant connection between physical health (inflammation, gut health, diet) and mental health, suggesting that addressing metabolic issues can be more effective than traditional talk therapy for conditions like depression.
- There is significant room for innovation in the food and grocery sectors to treat food as a direct healthcare intervention, moving beyond simple sourcing to actively participating in improving consumer health.
- The "Peating" diet community, which emphasizes high-energy, metabolically boosting foods, offers a contrarian yet potentially effective approach to personal health experimentation, challenging long-held nutritional dogma.
Conclusion
The US faces a significant chronic disease crisis stemming from an unhealthy environment and misaligned incentives, particularly within the food and healthcare systems.
Systemic solutions are needed, focusing on incentivizing prevention through accessible financial mechanisms like TruMed, reforming crop subsidies, and strengthening regulations on environmental toxins.
Embracing a more holistic view of health, integrating lifestyle interventions, and fostering individual experimentation with diets and therapies can lead to better health outcomes.
Discussion Topics
- How can we redesign our environment to make healthy choices the default rather than the exception?
- What policy changes are most crucial to shift healthcare incentives from treatment to prevention?
- How can technology and innovative business models better integrate food and lifestyle as core components of healthcare?
Key Terms
- Ultra-processed food
- Food manufactured from many ingredients, typically industrial ones, and including additives like artificial colors, flavors, emulsifiers, and preservatives.
- Crop subsidies
- Government payments or other benefits made to farmers to supplement their income, reduce the selling price of commodities, or make production more profitable.
- High fructose corn syrup (HFCS)
- A sweetener made from the starch of corn, which is then processed to make it sweeter. It is commonly used in processed foods and beverages.
- GLP-1 agonists
- A class of drugs that mimic the action of the hormone glucagon-like peptide-1, used to treat type 2 diabetes and promote weight loss by regulating appetite and blood sugar.
- FSA (Flexible Spending Account)
- An employer-sponsored benefit that allows employees to set aside pre-tax income to pay for qualified medical expenses.
- HSA (Health Savings Account)
- A savings account that allows individuals to set aside money on a pre-tax basis to pay for qualified medical expenses.
- Peptides
- Short chains of amino acids that can act as signaling molecules in the body, with potential therapeutic applications.
- Glyphosate
- A broad-spectrum systemic herbicide used to kill weeds, commonly found in products like Roundup.
- Metabolic psychiatry
- An emerging field that studies the link between metabolic health (e.g., inflammation, gut health, diet) and mental health conditions.
- Ketogenic diet
- A very low-carbohydrate, high-fat diet that forces the body to burn fat for fuel instead of carbohydrates.
Timeline
The modern U.S. environment is structurally designed to make people unhealthy, leading to high rates of chronic disease, obesity, and poor health outcomes compared to previous generations.
The 1970s marked a turning point for American health, with major food companies prioritizing profit by replacing real ingredients with cheaper, processed alternatives like high-fructose corn syrup and soybean oil due to shareholder pressure and optimized earnings per share.
US crop subsidies for corn, soy, and wheat artificially lower their cost, encouraging their widespread use in processed foods and contributing to the prevalence of unhealthy ingredients in the food system.
The current healthcare system incentivizes treating chronic diseases after they manifest rather than preventing them, as managing conditions like heart attacks is far more profitable than investing in preventative measures like exercise or healthy eating.
TruMed aims to solve this by enabling individuals to use tax-advantaged FSA/HSA dollars for lifestyle interventions like gym memberships and healthier food, treating prevention as a viable healthcare intervention.
The mismatch between human genes and the modern, toxic environment is a root cause of chronic disease, similar to how zoo animals exhibit health problems absent in their wild counterparts.
Addressing the health crisis requires systemic changes, including fixing crop subsidies, increasing investment in preventative care, and enacting stricter regulations on environmental toxins, mirroring the EU's approach to chemical safety.
GLP-1 medications like Ozempic can be a useful tool for initiating weight loss but are not a holistic solution, as they don't address the underlying issues of poor diet and environmental factors.
Psychedelics show promise as a powerful mental health intervention, especially for conditions like PTSD and depression, and should be further researched and integrated into treatment options.
Metabolic psychiatry highlights the significant connection between physical health (inflammation, gut health, diet) and mental health, suggesting that addressing metabolic issues can be more effective than traditional talk therapy for conditions like depression.
There is significant room for innovation in the food and grocery sectors to treat food as a direct healthcare intervention, moving beyond simple sourcing to actively participating in improving consumer health.
The "Peating" diet community, which emphasizes high-energy, metabolically boosting foods, offers a contrarian yet potentially effective approach to personal health experimentation, challenging long-held nutritional dogma.
Episode Details
- Podcast
- a16z Podcast
- Episode
- Why America’s Health Crisis Is an Incentive Problem
- Official Link
- https://a16z.com/podcasts/a16z-podcast/
- Published
- February 4, 2026